H2N2V1, France, Analysis, bibRecord, 000132

An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.

Identifieur interne : 000132 ( France/Analysis ); précédent : 000131; suivant : 000133

An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.

Auteurs : Cyrille Gavazzi [France] ; Catherine Isel [France] ; Emilie Fournier [France] ; Vincent Moules [France] ; Annie Cavalier [France] ; Daniel Thomas [France] ; Bruno Lina [France] ; Roland Marquet [France]

Source :

Nucleic Acids Research [ 0305-1048 ] ; 2013-01.

RBID : Hal:inserm-00870461

Abstract

The genome of influenza A viruses (IAV) is split into eight viral RNAs (vRNAs) that are encapsidated as viral ribonucleoproteins. The existence of a segment-specific packaging mechanism is well established, but the molecular basis of this mechanism remains to be deciphered. Selective packaging could be mediated by direct interaction between the vRNA packaging regions, but such interactions have never been demonstrated in virions. Recently, we showed that the eight vRNAs of a human H3N2 IAV form a single interaction network in vitro that involves regions of the vRNAs known to contain packaging signals in the case of H1N1 IAV strains. Here, we show that the eight vRNAs of an avian H5N2 IAV also form a single network of interactions in vitro, but, interestingly, the interactions and the regions of the vRNAs they involve differ from those described for the human H3N2 virus. We identified the vRNA sequences involved in five of these interactions at the nucleotide level, and in two cases, we validated the existence of the interaction using compensatory mutations in the interacting sequences. Electron tomography also revealed significant differences in the interactions taking place between viral ribonucleoproteins in H5N2 and H3N2 virions, despite their canonical '7 + 1' arrangement.

Url:

https://www.hal.inserm.fr/inserm-00870461

DOI: 10.1093/nar/gks1181

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000017
to stream Hal, to step Curation: 000017
to stream Hal, to step Checkpoint: 000167
to stream Main, to step Merge: 000795
to stream Main, to step Curation: 000794
to stream Main, to step Exploration: 000794
to stream France, to step Extraction: 000132

Links to Exploration step

Hal:inserm-00870461

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.</title>
<author><name sortKey="Gavazzi, Cyrille" sort="Gavazzi, Cyrille" uniqKey="Gavazzi C" first="Cyrille" last="Gavazzi">Cyrille Gavazzi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Isel, Catherine" sort="Isel, Catherine" uniqKey="Isel C" first="Catherine" last="Isel">Catherine Isel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Fournier, Emilie" sort="Fournier, Emilie" uniqKey="Fournier E" first="Emilie" last="Fournier">Emilie Fournier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Moules, Vincent" sort="Moules, Vincent" uniqKey="Moules V" first="Vincent" last="Moules">Vincent Moules</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-508819" status="OLD">          <idno type="RNSR">201119499B</idno>
          <orgName>Virologie et pathologie humaine</orgName>
          <orgName type="acronym">VirPath</orgName>
          <date type="start">2011-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA 4610" active="#struct-194495" type="direct"></relation>
            <relation active="#struct-301088" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle name="EA 4610" active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301088" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID">          <orgName>Université de Lyon</orgName>
          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Cavalier, Annie" sort="Cavalier, Annie" uniqKey="Cavalier A" first="Annie" last="Cavalier">Annie Cavalier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-187162" status="VALID">          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <desc>            <address>              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://igdr.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-105160" type="direct"></relation>
            <relation active="#struct-528860" type="indirect"></relation>
            <relation name="UMR6290" active="#struct-441569" type="direct"></relation>
            <relation active="#struct-453207" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID">          <orgName>Université de Rennes 1</orgName>
          <orgName type="acronym">UR1</orgName>
          <desc>            <address>              <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-528860" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID">          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UNIV-RENNES</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR6290" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID">          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
          <orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
          <desc>            <address>              <addrLine>Université Rennes 1 - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Thomas, Daniel" sort="Thomas, Daniel" uniqKey="Thomas D" first="Daniel" last="Thomas">Daniel Thomas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-187162" status="VALID">          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <desc>            <address>              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://igdr.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-105160" type="direct"></relation>
            <relation active="#struct-528860" type="indirect"></relation>
            <relation name="UMR6290" active="#struct-441569" type="direct"></relation>
            <relation active="#struct-453207" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID">          <orgName>Université de Rennes 1</orgName>
          <orgName type="acronym">UR1</orgName>
          <desc>            <address>              <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-528860" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID">          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UNIV-RENNES</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR6290" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID">          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
          <orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
          <desc>            <address>              <addrLine>Université Rennes 1 - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-508819" status="OLD">          <idno type="RNSR">201119499B</idno>
          <orgName>Virologie et pathologie humaine</orgName>
          <orgName type="acronym">VirPath</orgName>
          <date type="start">2011-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA 4610" active="#struct-194495" type="direct"></relation>
            <relation active="#struct-301088" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle name="EA 4610" active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301088" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID">          <orgName>Université de Lyon</orgName>
          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Marquet, Roland" sort="Marquet, Roland" uniqKey="Marquet R" first="Roland" last="Marquet">Roland Marquet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00870461</idno>
<idno type="halId">inserm-00870461</idno>
<idno type="halUri">https://www.hal.inserm.fr/inserm-00870461</idno>
<idno type="url">https://www.hal.inserm.fr/inserm-00870461</idno>
<idno type="doi">10.1093/nar/gks1181</idno>
<date when="2013-01">2013-01</date>
<idno type="wicri:Area/Hal/Corpus">000017</idno>
<idno type="wicri:Area/Hal/Curation">000017</idno>
<idno type="wicri:Area/Hal/Checkpoint">000167</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000167</idno>
<idno type="wicri:doubleKey">0305-1048:2013:Gavazzi C:an:in:vitro</idno>
<idno type="wicri:Area/Main/Merge">000795</idno>
<idno type="wicri:Area/Main/Curation">000794</idno>
<idno type="wicri:Area/Main/Exploration">000794</idno>
<idno type="wicri:Area/France/Extraction">000132</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.</title>
<author><name sortKey="Gavazzi, Cyrille" sort="Gavazzi, Cyrille" uniqKey="Gavazzi C" first="Cyrille" last="Gavazzi">Cyrille Gavazzi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Isel, Catherine" sort="Isel, Catherine" uniqKey="Isel C" first="Catherine" last="Isel">Catherine Isel</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Fournier, Emilie" sort="Fournier, Emilie" uniqKey="Fournier E" first="Emilie" last="Fournier">Emilie Fournier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Moules, Vincent" sort="Moules, Vincent" uniqKey="Moules V" first="Vincent" last="Moules">Vincent Moules</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-508819" status="OLD">          <idno type="RNSR">201119499B</idno>
          <orgName>Virologie et pathologie humaine</orgName>
          <orgName type="acronym">VirPath</orgName>
          <date type="start">2011-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA 4610" active="#struct-194495" type="direct"></relation>
            <relation active="#struct-301088" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle name="EA 4610" active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301088" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID">          <orgName>Université de Lyon</orgName>
          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Cavalier, Annie" sort="Cavalier, Annie" uniqKey="Cavalier A" first="Annie" last="Cavalier">Annie Cavalier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-187162" status="VALID">          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <desc>            <address>              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://igdr.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-105160" type="direct"></relation>
            <relation active="#struct-528860" type="indirect"></relation>
            <relation name="UMR6290" active="#struct-441569" type="direct"></relation>
            <relation active="#struct-453207" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID">          <orgName>Université de Rennes 1</orgName>
          <orgName type="acronym">UR1</orgName>
          <desc>            <address>              <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-528860" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID">          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UNIV-RENNES</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR6290" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID">          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
          <orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
          <desc>            <address>              <addrLine>Université Rennes 1 - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Thomas, Daniel" sort="Thomas, Daniel" uniqKey="Thomas D" first="Daniel" last="Thomas">Daniel Thomas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-187162" status="VALID">          <orgName>Institut de Génétique et Développement de Rennes</orgName>
          <orgName type="acronym">IGDR</orgName>
          <desc>            <address>              <addrLine>Faculté de Médecine - CS 34317 2 Av du Professeur Léon Bernard 35043 Rennes Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://igdr.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-105160" type="direct"></relation>
            <relation active="#struct-528860" type="indirect"></relation>
            <relation name="UMR6290" active="#struct-441569" type="direct"></relation>
            <relation active="#struct-453207" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID">          <orgName>Université de Rennes 1</orgName>
          <orgName type="acronym">UR1</orgName>
          <desc>            <address>              <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-rennes1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-528860" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-528860" type="indirect"><org type="regroupinstitution" xml:id="struct-528860" status="VALID">          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UNIV-RENNES</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR6290" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID">          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
          <orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
          <desc>            <address>              <addrLine>Université Rennes 1 - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-508819" status="OLD">          <idno type="RNSR">201119499B</idno>
          <orgName>Virologie et pathologie humaine</orgName>
          <orgName type="acronym">VirPath</orgName>
          <date type="start">2011-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="EA 4610" active="#struct-194495" type="direct"></relation>
            <relation active="#struct-301088" type="indirect"></relation>
          </listRelation>
        <tutelles><tutelle name="EA 4610" active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID">          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301088" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID">          <orgName>Université de Lyon</orgName>
          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Marquet, Roland" sort="Marquet, Roland" uniqKey="Marquet R" first="Roland" last="Marquet">Roland Marquet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18579" status="OLD">          <orgName>Architecture et réactivité de l'ARN</orgName>
          <orgName type="acronym">ARN</orgName>
          <desc>            <address>              <addrLine>Institut de Biologie Moléculaire et Cellulaire 15 rue René Descartes 67084 STRASBOURG Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www-ibmc.u-strasbg.fr/arn/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300320" type="direct"></relation>
            <relation name="UPR9002" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300320" type="direct"><org type="institution" xml:id="struct-300320" status="OLD">          <orgName>Université Louis Pasteur - Strasbourg I</orgName>
          <date type="start">1970-01-01</date>
          <date type="end">2008-01-01</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UPR9002" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Strasbourg</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
</placeName>
<orgName type="university">Université Strasbourg 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Strasbourg</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1093/nar/gks1181</idno>
<series><title level="j">Nucleic Acids Research</title>
<idno type="ISSN">0305-1048</idno>
<imprint><date type="datePub">2013-01</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>The genome of influenza A viruses (IAV) is split into eight viral RNAs (vRNAs) that are encapsidated as viral ribonucleoproteins. The existence of a segment-specific packaging mechanism is well established, but the molecular basis of this mechanism remains to be deciphered. Selective packaging could be mediated by direct interaction between the vRNA packaging regions, but such interactions have never been demonstrated in virions. Recently, we showed that the eight vRNAs of a human H3N2 IAV form a single interaction network in vitro that involves regions of the vRNAs known to contain packaging signals in the case of H1N1 IAV strains. Here, we show that the eight vRNAs of an avian H5N2 IAV also form a single network of interactions in vitro, but, interestingly, the interactions and the regions of the vRNAs they involve differ from those described for the human H3N2 virus. We identified the vRNA sequences involved in five of these interactions at the nucleotide level, and in two cases, we validated the existence of the interaction using compensatory mutations in the interacting sequences. Electron tomography also revealed significant differences in the interactions taking place between viral ribonucleoproteins in H5N2 and H3N2 virions, despite their canonical '7 + 1' arrangement.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Grand Est</li>
<li>Rhône-Alpes</li>
<li>Région Bretagne</li>
</region>
<settlement><li>Lyon</li>
<li>Rennes</li>
<li>Strasbourg</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université Strasbourg 1</li>
<li>Université de Lyon</li>
<li>Université de Rennes 1</li>
<li>Université de Strasbourg</li>
<li>Université européenne de Bretagne</li>
</orgName>
</list>
<tree><country name="France"><region name="Grand Est"><name sortKey="Gavazzi, Cyrille" sort="Gavazzi, Cyrille" uniqKey="Gavazzi C" first="Cyrille" last="Gavazzi">Cyrille Gavazzi</name>
</region>
<name sortKey="Cavalier, Annie" sort="Cavalier, Annie" uniqKey="Cavalier A" first="Annie" last="Cavalier">Annie Cavalier</name>
<name sortKey="Fournier, Emilie" sort="Fournier, Emilie" uniqKey="Fournier E" first="Emilie" last="Fournier">Emilie Fournier</name>
<name sortKey="Isel, Catherine" sort="Isel, Catherine" uniqKey="Isel C" first="Catherine" last="Isel">Catherine Isel</name>
<name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<name sortKey="Marquet, Roland" sort="Marquet, Roland" uniqKey="Marquet R" first="Roland" last="Marquet">Roland Marquet</name>
<name sortKey="Moules, Vincent" sort="Moules, Vincent" uniqKey="Moules V" first="Vincent" last="Moules">Vincent Moules</name>
<name sortKey="Thomas, Daniel" sort="Thomas, Daniel" uniqKey="Thomas D" first="Daniel" last="Thomas">Daniel Thomas</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000132 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000132 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Hal:inserm-00870461
   |texte=   An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.

An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri